Tranexamic Acid in Hip Reconstructions in Children with Cerebral Palsy .
Tranexamic Acid in Hip Reconstructions in Children with Cerebral Palsy: A Double-Blind Randomized Controlled Clinical Trial.
Children (Basel) . 2023 Dec 15;10(12):1931.Thirty-one patients with cerebral palsy undergoing surgical treatment for hip dislocation were randomized to receive either tranexamic acid (TXA; n=21) or a placebo (control; n=10). The outcomes of interest were intraoperative bleeding, preoperative and 24-hour postoperative hemoglobin concentrations, length of hospital stay (LHS), and the necessity for blood transfusions. Outcomes were assessed up to 24 hours post-surgery. Overall, the results of the study revealed that TXA significantly reduced intraoperative bleeding as compared to the control group. The drop in hemoglobin concentration was lower in the TXA group, though this was not statistically significant, and no significant difference in LHS or the number of transfusions was noted. Ultimately, these findings suggest the effectiveness of TXA in reducing intraoperative bleeding without significant impacts on other measured outcomes.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics