Topical Vancomycin For Reducing Surgical Site Infections After Spine Surgery: A Meta-Analysis .
Does the Application of Topical Vancomycin Reduce Surgical Site Infections in Spine Surgery? A Meta-analysis of Randomized Controlled Trials.
Clin Orthop Relat Res . 2024 Dec 1;482(12):2212-2219.Six randomized controlled trials, including 2,140 patients undergoing spine surgery, were analyzed in this meta-analysis to compare the efficacy of topical vancomycin versus no vancomycin in preventing surgical site infections (SSIs). Pooled outcomes included the risk of overall SSIs, deep SSIs, and superficial SSIs. The results showed no significant difference in the rates of overall SSIs, deep SSIs, or superficial SSIs between the vancomycin and control groups. The study concludes that the routine use of topical vancomycin in spine surgery does not significantly reduce the risk of infections and therefore is not recommended.
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