TNF antagonist better in treatment of early rheumatoid arthritis .
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Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial
Lancet. 2009 Aug 8;374(9688):459-66.258 patients with early stage rheumatoid arthritis, who were unresponsive to 4 months treatment with methotrexate, were randomized to receive additional treatment with Infliximab (tumor necrosis factor antagonist) or sulfasalazine and hydroxychloroquine. This trial assessed the efficacy of the use of tumor necrosis factor antagonists in treatment of rheumatoid arthritis, while comparing this treatment to other antirheumatic drugs. The results from this trial indicated that Inifliximab produced a greater number of improved patients when compared to the sulfasalazine and hydroxychloroquine group.
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