18 randomized controlled trials (937 patients; 1093 TKAs) comparing the mini-midvastus and parapatellar approaches in patients undergoing total knee arthroplasty (TKA) were included in this meta-analysis. The purpose of this review was to compare these two treatment approaches with respect to postoperative pain, function and complications. Pooled data indicated that, although associated with a significantly longer operative time, the mini-midvastus approach yielded significantly better pain scores and range of motion at 1-2 weeks post-operation, compared to the parapatellar approach. Furthermore, both groups exhibited similar Knee Society Scores, rates of lateral retinacular release, blood loss, straight leg raise, hospital stay and postoperative complications.