TKA: Dual-opioid treatment reduces pain and adverse GI events vs. oxycodone/acetaminophen .
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty
Clin Ther. 2013 Apr;35(4):498-511. doi: 10.1016/j.clinthera.2013.03.00244 patients who underwent either TKA or THA (31 of whom completed the study) were randomized to receive either a fixed dose of morphine/oxycodone, a flexible dose of morphine/oxycodone or oxycodone/acetaminophen to compare the efficacy of these analgesic treatments. Results indicated that the morphine/oxycodone flexible dose group experienced a 20% decrease in the time-weighted sum of pain intensity difference from 0 to 48 hours (SPID-48) and 3 times less moderate to severe adverse gastrointestinal events when compared to the oxycodone/acetaminophen group.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
