Tibolone reduces fracture risk in osteoporotic women but increases stroke risk .
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The Effects of Tibolone in Older Postmenopausal Women
N Engl J Med. 2008 Aug 14;359(7):697-7084538 post-menopausal women (age 60-85) with low bone mineral density were randomized to either receive a daily dose of Tibolone (1.25mg) or an identical placebo. The results indicated that the use of tibolone resulted in a reduced risk for developing vertebral and non-vertebral fractures, invasive breast cancer as well as colon cancer. However, it is important to note that tibolone did increase the risk for stroke, and therefore should not be used as treatment in elderly women with other risk factors for stroke.
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