The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):72 Psychopharmacology (Berl). 2019 23-Feb;():. 10.1007/s00213-018-5119-xWhat this means for my practice?
Results suggest that microdose LSD produces a tendency to over-reproduce suprasecond temporal intervals in older adults. Given the role of interval timing across a range of psychological functions, distorted timing under LSD may contribute to, or underlie, broader cognitive and perceptual effects of this drug. Additional evidence from self-report measures suggests that the observed effects are unlikely to be attributable to altered states of consciousness. Further research is required to replicate these results, including their interval specificity, and identify the neurochemical and cognitive mediators of distorted timing under micro- and psychoactive doses of LSD.
Study Summary
In this randomised, double-blind, placebo-controlled study examining the effects of microdose lysergic acid diethylamide (LSD) on time perception, 48 healthy older adults were were randomly assigned to one of four cohorts receiving either placebo or 5, 10, and 20 μg of LSD. Subjective drug effects were assessed using the Subjective Drug Effects Visual Analogue Scale (SDEVAS) and interval timing was assessed using a temporal reproduction task. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition.
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