284 older (>55 years of age), overweight/obese adults with grade II-III radiographic tibiofemoral osteoarthritis (OA) or tibiofemoral plus patellofemoral OA, were randomly assigned to 1 of 3 groups to determine the effect dietary-induced weight loss or weight loss plus exercise had on bone mineral density (BMD). Patients took part in a dietary intervention, an exercise intervention, or a combination of the two. Results from the study demonstrated that patients in all three groups lost a significant amount of weight when compared to baseline measurements. Significant treatment effects were observed for BMD of the hip and femoral neck regions, with the diet group and diet plus exercise group demonstrating similar relative losses. Results of the study also indicated that BMD correlated positively with changes in body weight.