The effect of topical tranexamic acid on blood loss following TKA or THA .
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Topical administration of tranexamic acid in primary total hip and total knee arthroplasty
J Arthroplasty. 2014 May;29(5):889-94100 patients (50 TKA and 50 THA) who were over the age of 18 and scheduled to receive either TKA or THA, were randomly assigned into 1 of 2 groups (an intervention and a placebo) to determine the effect that topical tranexamic acid, applied at the joint space immediately prior to joint closure for TKA and THA, had on blood loss in patients following surgery. The results of the study demonstrated that tranexamic acid lead to significantly higher postoperative hemoglobin level when compared to placebo treatment. A numerical improvement in the amount of blood transfused was indicated in patients who received treatment with topical tranexamic acid, but the amount did not differ significantly from those in the comparison group. No significant increase in complications was noted in patients who received tranexamic intervention.
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