The effect of 3 versus 6 years of zoledronic acid treatment on femoral neck-BMD .
The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)
J Bone Miner Res. 2012 Feb;27(2):243-54. doi: 10.1002/jbmr.1494This study was conducted to examine the long-term effects of zoledronic acid (ZOL) on bone mineral density (BMD) and fracture risk. 1233 postmenopausal women who received ZOL for 3 years in the previous study were randomized and received either 3 additional years of zoledronic acid or placebo. Results at 6 years revealed that between years 3 and 6, femoral neck-BMD remained constant in patients who received zoledronic acid and dropped slightly for those who received a placebo; however, the values remained above pre-treatment levels for both groups.
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