Comparison between teriparatide and bisphosphonates for improving bone mineral density in postmenopausal osteoporosis patients: A meta-analysis.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2020;8(20):6 Medicine (Baltimore). 2020 Apr; 99(15): e18964.What this means for my practice?
Study findings suggest that teriparatide may result in a significantly lower risk of vertebral and non-vertebral fractures, as well as higher bone mineral density when compared to bisphosphonates in elderly women with postmenopausal osteoporosis. However, this study lacked quality of life outcomes, and included several different types of bisphosphonates, which were considered limitations of the study. Furthermore, the follow- up duration of the included studies was relatively short. Future studies are required to confirm the findings.
Study Summary
Fourteen studies were included in this meta-analysis comparing teriparatide and bisphosphonates for the improvement in bone mineral density and reduction of fracture incidence in postmenopausal women with osteoporosis. The outcomes of interest included the pooled incidence of vertebral and nonvertebral fractures, bone mineral density of the lumbar spine and femoral neck, and the incidence of adverse events. A statistically significantly lower pooled occurrence of vertebral (p=0.001) and nonvertebral fractures (p=0.009) were observed in favour of the teriparatide group. Moreover, pooled bone mineral density in the lumbar spine and femoral neck were statistically significantly in favour of the teriparatide group (p<0.001 for both). No statistical significant differences in the pooled incidence of adverse events were observed between the two groups (p=0.516).
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