The efficacy of temperature intervention combined with tranexamic acid in reducing blood loss and accelerating recovery during spinal fusion.

研究概要

Three hundred ten patients undergoing traditional lumbar spinal fusion were randomized into four groups: Group A (placebo; no tranexamic acid [TXA] or temperature intervention, n=78), Group B (TXA only, n=77), Group C (TXA with temperature intervention, n=77), and Group D (temperature intervention only, n=78). The primary outcomes were intraoperative, postoperative, and total blood loss. Secondary outcomes included hemoglobin levels on postoperative day 1 (POD1), blood transfusion rates, prothrombin time, length of hospital stay, and incidence of deep vein thrombosis or pulmonary embolism. Outcomes were assessed up to 3 months postoperatively. Overall, the results demonstrated that Group C had significantly lower blood loss, higher hemoglobin levels on POD1, reduced transfusion rates, and shorter hospital stays compared to the other groups (P < .05). The findings suggest that combining TXA and temperature intervention enhances perioperative outcomes without increasing thrombotic complications.