Tanezumab reduces osteoarthritic knee pain but increases adverse events .
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Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial
J Pain. 2012 Aug;13(8):790-8. doi: 10.1016/j.jpain.2012.05.006. Epub 2012 Jul 10.690 patients with osteoarthritis of the knee were randomized to receive 2.5 mg of tanezumab, 5 mg of tanezumab, 10 mg of tanezumab, or a placebo. The results of the study indicate that the patients treated with tanezumab experienced a significant improvement in knee pain and function, but also an incidence of adverse events of 55 to 60%. It should be noted that the tanezumab osteoarthritis clinical trial is on hold due to potential adverse events leading to joint replacement.
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