Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind, placebo-controlled trial
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(14):26 Pain. 2022 01-Jun;():. 10.1097/j.pain.0000000000002466What this means for my practice?
The results of this trial found no significant differences between CBD in addition to conventional pain management and conventional pain management alone in all outcomes. Future trials should consider assessing the analgesic effects of higher doses of CBD on pain management for PsA and Hand-OA and other pain disorders.
Study Summary
One hundred and thirty-six patients with psoriatic arthritis and hand arthritis were randomized to receive either synthetic cannabidiol as an add-on to conventional pain management (n=70) or conventional pain management (n=66). The primary outcome of this trial was to determine the pain intensity using a Visual Analog Scale (VAS) after 12 weeks of treatment. Other outcomes such as Hospital Anxiety and Depression (HADS), Pittsburgh Sleep Quality Index (PSQI), Pain Catastrophizing Scale (PCS), Health Assessment Questionnaire Disability Index, and Stanford Expectation of Treatment Scale were recorded. The results of this trial showed no significant differences between the two treatment groups in regard to pain scores, anxiety, depression, disability, pain catastrophizing, and sleep quality.
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