Synovial biomarkers and clincial scores of Orthovisc versus Hylan G-F20 in knee OA treatment .
Effects of different hyaluronic acid products on synovial fluid levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in knee osteoarthritis.
Ann Clin Lab Sci. 2004 Summer;34(3):330-540 patients with knee osteoarthritis were randomized to three weekly injections of either Orthovisc (Anika Therapeutics) or Hylan G-F20 (Synvisc; Genzyme). Primary outcomes were synovial fluid concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Clinical outcome on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was also assessed. Results demonstrated significant within-group reductions in both groups for ICAM-1, VCAM-1, and WOMAC scores from baseline to 3 weeks, with no significant between-group differences observed.
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