2024 EFORT Annual Meeting: Surgical fascioectomy versus collagenase injection in treating recurrent dupuytren disease: 1-year results of a randomized controlled trial

Sixty patients with recurrent Dupuytren contracture were randomized to receive either surgical fasciectomy (n=29) or collagenase injection (n=31). The primary outcome of interest was the total active extension deficit (TAED) in the treated fingers. Secondary outcomes included QuickDASH score, pain score, EQ-5D index, and patient satisfaction score. Outcomes were assessed at baseline, 12, and 52 weeks. Overall, the results of the study revealed significant improvements in TAED in both groups, with mean improvements of 51° in the fasciectomy group and 42° in the collagenase group. There were no statistically significant differences between the two groups in primary or secondary outcomes at 1 year. Both treatments showed similar patient satisfaction scores and adverse event profiles. These findings suggest that both surgical fasciectomy and collagenase injection are effective for treating recurrent Dupuytren contracture, with no significant difference in efficacy or patient satisfaction.