Subacute effects of the psychedelic ayahuasca on the salience and default mode networks

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

Fifty healthy participants were randomized to receive a single oral low dose of 1mL/kg of ayahuasca or placebo in this randomized placebo-controlled trial investigating the subacute effects of ayahuasca. Subjective drug effects were assessed using the Hallucinogenic Rating Scale (HRS). Neuroimages were acquired using resting state fMRI and inter- and intra-network functional connectivity analyses were performed using generated salience, visual, sensorimotor, and default mode network maps. Primary sensory networks did not show subacute changes in functional connectivity. One day after ayahuasca administration, there was increased anterior cingulate cortex connectivity within the salience network compared to placebo, which correlated with altered somesthesia scores. Decreased posterior cingulate cortex connectivity was also found within the default mode network, which correlated with altered volition scores. Additionally, following ayahuasca use, there was increased connectivity between the salience and default mode networks, which correlated with altered affect scores.