Eleven studies were included in this meta-analysis assessing the effect of spinal mobilization and manipulation interventions vs control on cardiovascular parameters in healthy patients and patients with spinal conditions or hypertension. The pooled outcomes of interest included systolic and diastolic blood pressure, as well as heart rate. Moreover, subgroup analyses were performed for healthy patients, and patients with hypertension or spinal pain. Results of this study revealed statistically significantly lower pooled systolic blood pressure in the spinal mobilization group for patients with spinal pain or hypertension (p=0.02). No statistical significant differences were observed between the two groups in pooled diastolic blood pressure and heart rate, both in the overall analysis and subgroup analyses (p>0.05 for all). Pooled systolic blood pressure in the overall analysis (p=0.05) and the subgroup analysis for healthy patients (p=0.48) were not statistically different between groups.