Spatiotemporal brain dynamics of emotional face processing modulations induced by the serotonin 1A/2A receptor agonist psilocybin
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):16 Cereb Cortex. 2014 23-Feb;():. 10.1093/cercor/bht178What this means for my practice?
Over the 168-189 ms poststimulus interval, there was a reduced neurophysiological response to both neutral and fearful faces within bilateral limbic areas including the amygdala and parahippocampal gyrus, the right fusiform gyrus, the temporoparietal cortices and prefrontal areas. Over the 211-242 ms period, there was a reduced response to happy faces within the right lingual gyrus, fusiform gyrus, middle-inferior occipital gyrus, bilateral limbic areas, temporoparietal cortices and the prefrontal areas. These findings are consistent with previous fMRI studies that have found the same regions to be involved with emotional processing. These results indicate a selective and temporally dissociable effect of psilocybin on the neuronal correlates of emotional face processing.
Study Summary
Thirty healthy subjects underwent a randomized, double-blind, placebo-controlled study design to examine the spatiotemporal brain mechanisms underlying emotional face processing modulations induced by psilocybin. Subjects received both psilocybin and a placebo two weeks apart. EEG analyses were applied to subjects' visual evoked potentials in response to emotional faces. Two time periods of strength (electric field) were observed over the 168-189 ms and 211-242 ms poststimulus intervals. For the 168-189 ms interval, there was reduced activity to both neutral and fearful faces within the limbic areas and the right temporal cortex. For the 211-242 ms interval, there was reduced activity to happy faces within the limbic areas.
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