Sodium hyaluronate is effective and well tolerated treatment for persistent shoulder pain .
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Treatment of Persistent Shoulder Pain with Sodium Hyaluronate: A Randomized, Controlled Trial - A Multicenter Study
J Bone Joint Surg Am. 2008 May;90(5):970-9.660 patients (>35 yr old) with persistent shoulder pain and limitation, resulting from glenohumeral joint osteoarthritis, rotator cuff tear, and/or adhesive capsulitis, were randomized to receive either 5 weekly injections of sodium hyaluronate, 3 weekly injections of sodium hyaluronate followed by 2 weekly injections of saline, or to 5 weekly injections of saline. Although sodium hyaluronate failed to cause symptomatic improvement at 13 weeks,overall, it had a favorable safety profile and was effective and well tolerated, as a nonoperative treatment of osteoarthritis in persistent shoulder pain refractory.
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