SHOULDER & ELBOW
Are Platelet-Rich Products Necessary during the Arthroscopic Repair of Full-Thickness Rotator Cuff Tears: A Meta-Analysis
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(16):31 PLoS One. 2013 Jul 12;8(7):e69731. doi: 10.1371/journal.pone.0069731. Print 2013Seven studies were included in this meta-analysis which aimed to determine the effect of the application of platelet-rich products (PRP) in arthroscopic rotator cuff repair. Pooled analyses of functional outcome measurements indicated no beneficial effect of PRP at a minimum of 12 months postoperatively, and overall no decrease in retear rate. However, an analysis of small to medium tears, exclusively, indicated a lower rate of retear when PRP had been applied.
Were the search methods used to find evidence (original research) on the primary question or questions stated?
Was the search for evidence reasonably comprehensive?
Were the criteria used for deciding which studies to include in the overview reported?
Was the bias in the selection of studies avoided?
Were the criteria used for assessing the validity of the included studies reported?
Was the validity of all of the studies referred to in the text assessed with use of appropriate criteria (either in selecting the studies for inclusion or in analyzing the studies that were cited)?
Were the methods used to combine the findings of the relevant studies (to reach a conclusion) reported?
Were the findings of the relevant studies combined appropriately relative to the primary question that the overview addresses?
Were the conclusions made by the author or authors supported by the data and or analysis reported in the overview?
How would you rate the scientific quality of this evidence?
Ja = 1
Ungewiss = 0.5
Nicht relevant = 0
Nein = 0
Die Bewertung der Berichtskriterien bewertet die Transparenz, mit der die Autoren die methodischen und studienspezifischen Merkmale der Studie in der Veröffentlichung angeben. Die Bewertung ist in fünf Kategorien unterteilt, die im Folgenden vorgestellt werden.
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Introduction
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Accessing Data
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Analysing Data
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Results
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Discussion
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
Der Fragilitätsindex ist ein Instrument, das bei der Interpretation signifikanter Ergebnisse hilft und ein Maß für die Stärke eines Ergebnisses liefert. Der Fragilitätsindex gibt die Anzahl der aufeinanderfolgenden Ereignisse an, die zu einem dichotomen Ergebnis hinzugefügt werden müssen, damit das Ergebnis nicht mehr signifikant ist. Eine kleine Zahl steht für ein schwächeres Ergebnis und eine große Zahl für ein stärkeres Ergebnis.
Warum wurde diese Studie jetzt benötigt?
Healing following arthroscopic rotator cuff repair remains an issue for a number of patients. The relatively high rate of retear has led to interest in techniques and products that may aid in the healing process. Recently, popularity has surrounded biological augmentation with platelet-rich products (PRP). Despite numerous studies advocating the promising results of PRP, as well as FDA approval, there still remains limited high quality evidence to support its application into standard clinical practice.
Was war die wichtigste Forschungsfrage?
In a meta-analysis of studies of Level I and II evidence, did rotator cuff repair augmented with PRP provide any advantageous clinical or radiological outcome compared to repair without PRP?
Was waren die wichtigsten Ergebnisse?
- A total of 7 studies were selected for inclusion in this meta-analysis: 6 randomized controlled trials and 1 prospective cohort study.
- Three studies were able to be pooled each for the Constant Score, ASES Score, and UCLA Score. All three of these functional outcome measures demonstrated no significant difference between groups who received PRP and groups that did not (Constant: MD 0.73 (95%CI -1.87 to 3.27); P=0.58) (ASES: MD -2.89 (95%CI -6.31 to 0.53); P=0.10) (UCLA: MD -0.79 (95%CI -2.20 to 0.63); P=0.28).
- Pooling of SST scores indicated a borderline significant finding in favor of control treatment over PRP application (MD 0.34 (95%CI -0.01 to 0.69); P=0.05).
- Retear rate among 5 studies revealed no significant difference between repair with and without PRP application (RR 0.71 (95%CI 0.48-1.05); P=0.08). However, a separate analysis considering small-medium tears exclusively found a significantly lower rate of retear of those treated with PRP (RR 0.33 (95%CI 0.12-0.91); P=0.03). The difference remained non-significant in large-massive tears only (RR 0.86 (95%CI 0.60-1.23); P=0.42).
Was sollte ich mir besonders merken?
The application of platelet-rich products in arthroscopic rotator cuff repair did not improve functional outcome at a minimum of 12 months when compared to non-augmented repair. Patients with small to medium tears and treated with PRP experienced significantly fewer incidences of retear.
Wie wird sich dies auf die Behandlung meiner Patienten auswirken?
Platelet-rich plasma does not appear to provide any additional benefit concerning functional outcome following rotator cuff repair. Further investigation into the use of PRP-like products in small to medium tears may be warranted, considering the lower rate of retear noted among groups that were treated with PRP application. This may suggest that the severity of the rotator cuff tear may contribute as a prognostic factor in the efficacy of PRP, but these results should be considered as hypothesis-generating only.
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