Single injection of hyaluronic acid not recommended for ankle osteoarthritis treatment .
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Intra-articular injection of hyaluronic acid is not superior to saline solution injection for ankle arthritis: a randomized, double-blind, placebo-controlled study
J Bone Joint Surg Am. 2012 Jan 4;94(1):2-864 patients presenting with osteoarthritis of the ankle were randomized to treatment receiving a single intra-articular injection with low molecular weight, non-cross linked hyaluronic acid or saline solution. The results measured at 16 weeks indicated that the hyaluronic acid treatment provided a significant reduction in American Orthopedic Foot and Ankle Society (AOFAS) score when compared to base line measures. A similar difference was not seen in the control group;however, there were no significant differences observed between the two groups for any measure throughout the study.
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