Single and 2 PRP injections provide similar short term pain reduction in knee OA patients .
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Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial
Am J Sports Med. 2013 Feb;41(2):356-64. doi: 10.1177/0363546512471299. Epub 2013 Jan 878 patients with bilateral knee osteoarthritis (OA) were randomized to receive 1 or 2 injections of platelet-rich plasma (PRP), or 1 injection of saline, to compare the effect of the injections on pain and function. The results displayed that 1 injection of PRP and 2 injections of PRP provided similar reductions in pain for knee OA patients and were more effective than saline injections. However, by 6 months improvements in pain from PRP injections deteriorated, suggesting that PRP injections are only effective in the short term.
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