Similar reduction in total blood loss with intravenous/articular TXA administration in TKA .
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One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration
Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.31 randomized control trials (RCT) comparing total blood loss (TBL) and transfusion rates in patients undergoing total knee arthroplasty (TKA) were included. The meta- analysis found that while both intravenous (IV)and intraarticular (IA) tranexamic acid (TXA)significantly reduced TBL and the incidence of blood transfusions, the two methods did not differ in the total blood loss reduction. Additionally, no significant difference was seen in the occurrence of thromboembolic events resulting from IV administration in comparison to IA administration.
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