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Osteoarthritis

Similar outcome with intraarticular BoNT-A injection vs HA + exercise program for ankle OA

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OSTEOARTHRITIS

Similar outcome with intraarticular BoNT-A injection vs HA + exercise program for ankle OA .

This report has been verified by one or more authors of the original publication.

Efficacy of intraarticular botulinum toxin A and intraarticular hyaluronate plus rehabilitation exercise in patients with unilateral ankle osteoarthritis: a randomized controlled trial

J Foot Ankle Res. 2014 Feb 6;7(1):9. doi: 10.1186/1757-1146-7-9.

Contributing Authors

SF Sun CW Hsu HS Lin YJ Chou JY Chen JL Wang

Seventy-five patients with ankle osteoarthritis (OA) were randomized to receive either an intraarticular injection of botulinum toxin A (BoNT-A) or an intraarticular injection of hyaluronate with a home-based exercise program. The purpose of this study was to compare the efficacy of these two conservative treatment approaches with respect to clinical and functional outcomes. Results at 6 months indicated that there were no significant differences between groups with respect to Ankle Osteoarthritis Scale (AOS) scores, American Orthopedic Foot and Ankle Society (AOFAS) Ankle/Hindfoot scores, pain, single-leg stance test (SLS) scores, the Timed Up-and-Go test (TUG), patient global satisfaction, acetaminophen consumption, and the incidence of adverse events.

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