Comparison of oral versus intravenous tranexamic acid in total knee and hip arthroplasty: A GRADE analysis and meta-analysis
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original publication.
Vol. 8 Iss. 22 | November 2020 | Number 11
Medicine (Baltimore) . 2020 Oct 30;99(44):e22999
Study Summary
Ten randomized controlled trials with a total of 1080 patients undergoing a total hip arthroplasty (THA) or total knee arthroplasty (TKA) were included in this meta-analysis comparing oral tranexamic acid (TXA) or intravenous (IV) TXA. The primary outcomes of interest included Hemoglobin (Hb) drop, total blood loss, and transfusion rate. Secondary outcomes of interest included drain blood loss, length of hospital stay, incidence of deep venous thrombosis (DVT), and the incidence of calf muscular vein thrombosis (CMVT). The pooled results demonstrated no statistically significantly differences between the oral or IV TXA groups in all primary or secondary outcomes.
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