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Arthroplasty

Similar Adverse Events & Complications with Aspirin vs Enoxparin for Hip/Knee Arthroplasty Patients

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ARTHROPLASTY

Similar Adverse Events & Complications with Aspirin vs Enoxparin for Hip/Knee Arthroplasty Patients .

This report has been verified by one or more authors of the original publication.

Aspirin versus enoxaparin for the initial prevention of venous thromboembolism following elective arthroplasty of the hip or knee: A systematic review and meta-analysis

Orthop Traumatol Surg Res. 2021 Feb;107(1): 102606.

Contributing Authors

JE Farey VVG An V Sidhu S Karunaratne IA Harris

Four randomized controlled trials including 1507 adult patients with osteoarthritis (OA) undergoing an elective hip or knee arthroplasty were included in this meta-analysis comparing the use of aspirin to enoxaparin after surgery for thromboprophylaxis. The primary outcomes of interest included incidence of venous thromboembolism (VTE) and mortality, which were evaluated up to 3-months post-surgery. Secondary outcomes of interest included the incidence of major bleeding events (i.e. re-operation due to organ, limb or muscle function compromise) and minor bleeding events (i.e. infection, wound ooze/minor bleed). Pooled results revealed that no statistical significant difference were observed for all primary and secondary outcomes (p>0.05 for all).

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