Mid-term results show no significant difference in postoperative clinical outcome, pain and range of motion between a well-established total knee arthroplasty design and its successor: a prospective, randomized, controlled trial
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(7):5 Knee Surg Sports Traumatol Arthrosc . 2021 Mar;29(3):827-831.What this means for my practice?
Study findings suggest that the Attune prosthesis system does not provide any clinical advantages over PFC Sigma prosthesis system with respect to pain, range of motion, and function at 2-years follow-up. However, this study did not incorporate blinding of patients or outcome assessors which could have increased biased in the results. Furthermore, a high drop-out rate was observed and quality of life outcomes were lacking in this study. Therefore, future randomized controlled trials are required incorporating blinding and a wide range of outcomes are needed to help confirm the findings of this trial.
Study Summary
Two hundred patients scheduled to undergo a primary total knee arthroplasty (TKA) for severe knee osteoarthritis were randomized to receive an Attune prosthesis (n=100) or Press Fit Condylar (PFC) Sigma prosthesis (n=100). Outcomes of interest included the following: Knee Society Knee and Function Scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), pain on a Visual Analogue Scale (VAS0, and range of motion (ROM). All outcomes were measured at 2-years follow-up. Results demonstrated that all outcomes were not statistically significantly different between the 2 prosthesis systems (p>0.05 for all).
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