2025 SICOT Annual Meeting: Peri-Operative Oral Protein Supplementation Improves Muscle Power And Serum Biomarkers After Fragility Hip Fracture: A Systematic Review And Meta-Analysis

Ten randomized controlled trials involving 648 patients with fragility hip fractures were included in this systematic review and meta-analysis comparing peri-operative oral protein supplementation versus standard care. Pooled outcomes of interest included handgrip strength, serum IGF-1, CRP, albumin, hospital stay, body weight, mobility, and quality of life. Protein supplementation significantly improved handgrip strength (+3.5 kg, p<0.001) and serum IGF-1 levels (p<0.001). Non-significant trends were noted for shorter hospital stay, reduced CRP, higher albumin, weight gain, and functional mobility. Overall, peri-operative protein supplementation appears to be a low-cost, low-risk strategy that enhances recovery after hip fracture surgery.