Short-term effect of extended- vs immediate-release triamcinolone acetonide for knee OA .
An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee: a randomized clinical trial
J Bone Joint Surg Am. 2015 Jun 3;97(11):877-88229 patients with unilateral or bilateral and mild-moderate knee osteoarthritis (Kellgren-Lawrence Grade 2-3) were included in this study to determine the comparative efficacy of extended-release triamcinolone acetonide compared to immediate-release triamcinolone acetonide. Patients were randomized into 1 of 3 groups receiving extended-release triamcinolone acetonide (10, 40 or 60 mg) or to the control group receiving 40 mg of immediate-release triamcinolone acetonide. Mean daily pain was measured over a 12 week period. Results indicated that 40 mg extended-release triamcinolone acetonide significantly reduced pain compared to immediate-release at 8 and 10 weeks.
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