SABER-Bupivacaine for Post-Operative Pain and Opioid Consumption for Subacromial Decompression .
SABER-Bupivacaine Reduces Postoperative Pain and Opioid Consumption After Arthroscopic Subacromial Decompression: A Randomized, Placebo-Controlled Trial
J Am Acad Orthop Surg Glob Res Rev . 2022 May 1;6(5).One hundred and seven patients undergoing an arthroscopic subacromial decompression (ASD) surgery were randomized (in a 2:1:1 ratio) to receive either sucrose acetate isobutyrate extended-release (SABER) bupivacaine (n=53), SABER-placebo (n=25), or bupivacaine HCl (n=29) to minimize post-operative pain and opioid consumption. The primary outcomes of this trial were to assess pain scores and analgesic use post-operation. Additional outcomes that were assessed were the short- and long-term safety of these formulations. The results of this trial showed significant reductions in pain intensity and opioid use after 72 hours in the SABER-Bupivacaine group when compared to the SABER-placebo.
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