Routine Sterile Glove & Instrument Change at Wound Closure for Prevention of Surgical Site Infection .
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Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection (ChEETAh): a pragmatic, cluster-randomised trial in seven low-income and middle-income countries
Lancet. 2022 Nov 19;400(10365):1767-1776.13,301 patients undergoing non-cesarean abdominal surgery were included in this cluster randomized trial in 7 low- and middle-income countries to assess whether the routine change of gloves and instruments before wound closure reduced the risk of surgical site infection. 7,157 were randomized to current/standard practice and 6,144 were randomized to the intervention group. The primary outcome of interest was surgical site infection within 30 days of surgery. Secondary outcomes of interest included mortality, surgical site infection at discharge, readmission, reoperation, return to normal activity, and length of hospital stay. The results revealed a robust benefit of routine glove/instrument change, which significantly lowered the risk of surgical site infection. No differences in secondary outcomes were observed.
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