Rheological properties of commercially available hyaluronic acid products in the United States for the treatment of osteoarthritis knee pain
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(22):27 Clinical Medical Insights Arthritis and Musculoskeletal Disorders. 2018;35:523-30What this means for my practice?
Available HA products vary with respect to molecular weight, presence of cross-linking, shear rate dependency, and crossover frequency. This analysis suggests that Euflexxa and Orthovisc are most similar to healthy knee HA in terms of the viscoelastic parameters studied. Euflexxa has a molecular weight closer to that of healthy knee HA compared to Orthovisc. Since IA-HA treatment for osteoarthritis aims to restore synovial fluid back to original HA property characteristics, the use of a product that most closely resembles healthy knee HA is a logical choice.
Study Summary
The rheological properties of Euflexxa, Orthovisc, Supartz, Monovisc, Synvisc, Synvisc-One, Gel-One and Hyalgan intra-articular hyaluronic acid (IA-HA) products used to treat knee osteoarthritis (OA) were obtained. The values for molecular weight, cross-linking, shear rate and crossover frequency parameters were then compared to the values for healthy knee synovial fluid reported within the current literature.
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