rhBMP-7 results in higher union rates compared to PRP in treatment of long bone non-unions .
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Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions - A prospective randomised clinical study on 120 patients
Injury. 2008 Dec;39(12):1391-402. Epub 2008 Nov 22120 patients with persistent long bone fracture non-unions were randomized to either receive recombinant bone morphogenic protein (rhBMP-7) or platelet-rich plasma (PRP). The results at a mean follow-up of 12 months indicated that rhBMP-7 had superior clinical and radiographic effectiveness compared to platelet-rich plasma. RhBMP-7 resulted in a greater percentage of non-unions that achieved clinical and radiological union, decreased healing time, and a lower failure rate.
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