Reduced blood loss during early postoperative period after TKA with IV tranexamic acid .
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients
Knee. 2006 Mar;13(2):106-10. Epub 2006 Feb 1729 patients undergoing primary unilateral total knee arthroplasty (TKA) were randomised to receive intravenous tranexamic acid or normal saline. The primary outcomes were early post-opeartive blood loss, and risk of thromboembolic complications. The results indicated that the tranexamic acid intervention significantly reduced blood loss during the early post-opeartive period. This intervention also did not appear to to increase the risk of thromboembolic complications.
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