Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d-methamphetamine in healthy volunteers. Results of an experimental double-blind placebo-controlled study
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):19 Psychopharmacology (Berl). 1999 23-Feb;():. 10.1007/s002130050860What this means for my practice?
The emotional effects of MDE were more uniformly positive and pleasant than the variable emotional effects of psilocybin. MDE also elicited the strongest and autonomic effects with increased plasma cortisol and prolactin levels, along with elevations of blood pressure, heart rate and body temperature. These findings illustrate a contrast between the psychological and autonomic effects (relaxation vs activation) of the MDE state. These findings are consistent with previous research on the effects of MDE and suggest that entactogens such as MDE constitute a distinctive, intermediate substance class between hallucinogens and stimulants.
Study Summary
Thirty-two healthy subjects underwent a double-blind, placebo-controlled, pseudo-randomized study to test the psychopathological, neuroendocrine and autonomic effects of the entactogen 3,4-methylenedioxyethylamphetamine (MDE), the hallucinogen psilocybin and the stimulant d-methamphetamine. Subjects were placed into four groups where they received either placebo, MDE, psilocybin or d-methamphetamine. The effects of MDE included pleasant emotional experiences of relaxation, peacefulness, content and closeness to others. MDE elicited the strongest endocrine and autonomic effects.
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