Psychological and cognitive effects of long-term peyote use among Native Americans
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):27 Biol Psychiatry. 2005 11-Apr;():. 10.1016/j.biopsych.2005.06.038What this means for my practice?
The long term use of peyote did not demonstrate deficits in mental health or cognitive function when compared to controls, while former alcohol abusers showed deficits in mental health and some cognitive function outcomes. This study is limited by the possibilites of selection bias, confounding factors, and lack of validation of the self-reported substance use of participants.
Study Summary
Three separate groups of Native Americans were recruited and tested on the Rand Mental Health Inventory (RMHI) and a battery of ten neuropsychological tests. The groups recruited consisted of 61 regular peyote users; 36 persons with past alcohol dependence; and 79 controls with minimal peyote, alcohol or other substance use. The peyote group showed no significant deficits in the RMHI or neuropsychological tests when compared to controls, while prior alcohol users showed significant deficits in all scales of the RMHI and two of the neuropsychological tests.
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