Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin. .
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Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers
Neuropsychopharmacology. 2012 23-Feb;():. 10.1038/npp.2011.228Sixteen healthy subjects underwent a double-blind, randomized, placebo-controlled, counterbalanced study to investigate whether psilocybin-induced deficits in automatic and controlled inhibition processes could be reduced by the 5-HT2A/C receptor antagonist, ketanserin. Subjects received placebo, ketanserin, psilocybin or psilocybin plus ketanserin. Automatic inhibition was measured by the prepulse inhibition (PPI) of the acoustic startle response. Controlled inhibition was measured by the Colour-Word Stroop Test. Under psilocybin, PPI was decreased at short intervals, and the number of errors increased on the interference condition of the Stroop Test. These changes were reduced by ketanserin pretreatment and ketanserin alone had no significant effects.
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