Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):24 J Psychopharmacol. 2018 23-Feb;():. 10.1177/0269881117731279What this means for my practice?
Psilocybin can facilitate enduring trait-level increases in prosocial attitudes/behaviours and in healthy psychological functioning. These enduring trait changes are determined by psilocybin-resulting mystical-type experiences and rates of spiritual practices. In comparison to the HD-SS group, the HD-HS showed greater persisting effects in terms of altruism/positive social effects, positive behaviour change and increased spirituality. The HD-HS group also showed greater effects on longitudinal measures of positive changes in interpersonal closeness, gratitude, forgiveness, and more. The results are limited by the homogeneity of the sample and the absence of a balanced 2x2 design, due to exclusion of a low dose, high spiritual support condition.
Study Summary
Seventy-five healthy subjects underwent a double-blind, placebo-controlled, randomized trial to test the effects of psilocybin on enduring changes in traits. Psilocybin was administered one and two months after subjects engaged in spiritual practice. In three groups, subjects in the very low dose group (active placebo) received standard support for spiritual practice (LD-SS), while the two high-dose groups received either standard or high spiritual practice support (HD-SS, HD-HS, respectively). In addition to acute psilocybin effects, assessment measures included enduring changes in prosocial attitudes and behaviours and psychological functioning. Both the high-dose groups showed greater acute and persisting effects, with large significant changes on longitudinal measures of interpersonal closeness, gratitude, life meaning/purpose, forgiveness, death transcendence, daily spiritual experiences, religious faith and coping and community observer ratings.
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