PRP reduces pain in knee osteoarthritis, but has no effect on physical function .
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A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis
Arthroscopy. 2012 Aug;28(8):1070-8. doi: 10.1016/j.arthro.2012.05.011176 patients were randomized to determine the efficacy of three intra-articular injections of plasma rich in growth factors (PRGF) versus hyaluronic acid (HA) injections in the treatment of symptomatic knee osteoarthritis. Clinical outcome using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) was measured over 6 months. The results indicated that a greater percentage of patients treated with the platelet-rich plasma (PRP) product experienced at least a 50% reduction in pain, however mean WOMAC pain, stiffness and function subscale scores did not significantly differ between treatments.
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