A Prospective Study Comparing Leukocyte-Poor Platelet-Rich Plasma Combined with Hyaluronic Acid and Autologous Microfragmented Adipose Tissue in Patients with Early Knee Osteoarthritis.
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(17):12 Stem Cells Dev. 2021 Jul 1;30(13): 651-659.Exclusive Author Interview
What this means for my practice?
Whilst both groups demonstrated significant clinical and functional improvement at 6 and 12 months, the results of this study demonstrated that a single injection of AMAT may provide an advantage over multiple PRP+HA injections in KOOS symptom scores at 6 months and Tegner scores at 6 and 12 months. This study was limited by the small sample size, difficulty in blinding patients, and short term follow up. Larger randomized trials with long term follow up are required to further assess the efficacy of the two treatments.
Study Summary
Fifty patients (80 knees) were randomized to receive a single injection of autologous microfragmented adipose tissue (AMAT; n=25, 40 knees) or 3 monthly injections of leukocyte-poor platelet-rich plasma (PRP) plus hyaluronic acid (HA) (n=25, 40 knees). The primary outcomes of interest were pain, symptoms and activity level. Outcomes were assessed at 6 and 12 months follow up. Results revealed no significant differences between the two groups in Visual Analog Scale (VAS) pain scores, Marx scores, or the sub-scores of Knee Injury and Osteoarthritis Outcome Score (KOOS) for pain, activities of daily living, sport, and quality of life at both 6 and 12 months follow up. However, KOOS symptoms scores at 6 months, as well as Tegner scores as 6 and 12 months, were significantly in favour of the AMAT group compared to the PRP+HA group.
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