541 patients, between the ages of 22 and 73, with symptomatic degenerative cervical disc disease were placed in 1 of 2 groups to test the safety and efficacy of cervical disc arthroplasty (CDA) compared to anterior cervical decompression and interbody fusion. Results demonstrated that patients in each group experienced improved NDI, SF-36 PCS, and neck and arm pain scores 5 years after treatment. All of these measurements were similar between the groups at final follow up, except for NDI, which was found to be significantly better in patients who received the CDA. Findings also differed between groups when looking at neurological success and secondary surgeries, showing that those who received CDA were more likely to have neurological success and less likely to go through secondary surgery (due to adverse events) following treatment.