Preop oral TXA demonstrates noninferiority to IV TXA in TKA for hemostasis .
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The James A. Rand Young Investigator's Award: A Randomized Controlled Trial of Oral and Intravenous Tranexamic Acid in Total Knee Arthroplasty: The Same Efficacy at Lower Cost?
J Arthroplasty. 2016 Sep;31(9 Suppl):26-3078 patients scheduled for total knee arthroplasty were randomized to be administered oral or intravenous tranexamic acid (TXA). The purpose of this study was to determine if oral TXA, which costs less, was noninferior to IV TXA. Outcomes included postoperative hemoglobin drop, total blood loss, postoperative drainage volume, transfusion rate, and the incidence of thromboembolic complications. Equivalence testing for hemoglobin drop and total blood loss demonstrated noninferior efficacy of oral TXA compared to IV TXA.
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