Preemptive Analgesia for Postoperative Pain & Morphine Consumption After Lumbar Spine Surgery .
Efficacy and safety of perioperative use of non-steroidal anti-inflammatory drugs for preemptive analgesia in lumbar spine surgery: a systematic review and meta-analysis.
Perioper Med (Lond) . 2023 Nov 23;12(1):61.12 randomized controlled trials (845 patients) comparing perioperative preemptive analgesia with non-steroidal anti-inflammatory drugs (NSAIDs) against a placebo were included in this systematic review and meta-analysis. The primary outcome of interest was morphine consumption. Secondary outcomes of interest included pain on a Visual Analog Scale (VAS) and Numeric Rating Scale (NRS), the incidence of nausea or vomiting, pruritus, dyspepsia, and constipation. Morphine consumption at 12 hours post-op, day 1, and day 2 was significantly lower in the NSAIDs group. VAS and NRS pain scores favored the NSAIDs group at all time points except for 12 hours post-operation. There were no significant differences in adverse events between the two groups.
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