One hundred eleven patients undergoing tibia fracture surgery were randomized to receive pre-emptive analgesia with either oxycodone (n=37), gabapentin (n=37), or diclofenac (n=37). The primary outcome of interest was postoperative pain (POP) assessed at multiple time points up to 24 hours after surgery. Secondary outcomes included sedation levels, postoperative opioid analgesic consumption, and medication side effects. Overall, the study found no significant differences between the groups in terms of postoperative pain, sedation, opioid consumption, or side effects, except at 6 hours post-surgery, where the gabapentin group had significantly lower pain scores compared to the other two groups. These findings suggest that while all three medications effectively reduce postoperative pain, gabapentin may provide a slight advantage at certain time points.