Single Intravenous Administration of Tranexamic Acid in Anterior Cruciate Ligament Reconstruction to Reduce Postoperative Hemarthrosis and Increase Functional Outcomes in the Early Phase of Postoperative Rehabilitation: A Randomized Controlled Trial

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80 patients scheduled for single-bundle anterior cruciate ligament reconstruction were randomized to intravenous administration of either 15mg/kg tranexamic acid or placebo saline. The study was conducted to determine if there was a significant difference between groups in 24-hour drainage volume. In addition, hemarthrosis grading, limb circumference, pain, quadriceps strength, functional scores, and complications were recorded up to 3 months postoperatively. Results demonstrated a significantly lower of postoperative blood loss volume in the TXA group compared to the placebo group. In addition, significant differences in favour of the TXA group were observed in hemarthrosis grading from 1 day to 2 weeks postoperatively, pain scores from 1 to 2 weeks postoperatively, and quadriceps strength from 1 to 2 weeks postoperatively. No notable postoperative complications, such as infection or deep vein thrombosis, were documented.,