Postoperative Antiosteoporotic Treatment with Zoledronic Acid vs Control in Post Menopausal Women .
Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Does Not Improve Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded, Randomized Study.
Arthroscopy . 2024 Mar;40(3):714-722.One hundred and twenty-four postmenopausal women with osteoporosis undergoing arthroscopic rotator cuff repair were randomized to receive zoledronic acid (n=61) or no antiosteoporotic treatment (n=63). The primary outcome was tendon healing, assessed by ultrasonography, while secondary outcomes included the ASES score, WORC index, and NRS for pain. Outcomes were measured at 6 weeks and 24 months postoperatively. Overall, the zoledronic acid group demonstrated a significantly higher tendon healing rate at 24 months, but no significant differences in clinical outcomes between the groups. These findings suggest that zoledronic acid reduces retear rates but does not enhance clinical outcomes in this patient population.
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