Sixty-four patients with patellofemoral pain syndrome were randomized to receive either positional release technique (PRT; n=32) or myofascial release technique (MFRT; n=32). The primary outcome of interest was pain reduction. Secondary outcomes of interest included function improvement, pressure pain threshold, muscle strength, and quality of life. Outcomes were assessed at baseline and six weeks post-intervention. Overall, the results of the study revealed significant reductions in pain and improvements in function, pressure pain threshold, muscle strength, and quality of life in both groups, with no significant differences between the groups. The findings suggest that both PRT and MFRT, combined with exercise therapy, are equally effective for managing patellofemoral pain syndrome.