"Platelet-Rich Plasma" epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

30 patients with lumbar disc herniations unresponsive to conservative treatment were randomized to receive an epidural injection of platelet-rich plasma (PRP; n=15) or triamcinolone (n=15). The primary outcome of interest was leg pain on a Visual Analog Scale (VAS). Additional outcomes of interest included back pain on a VAS, the Oswestry Disability Index (ODI) for function, the rate of adverse events, and treatment failure. Outcomes were assessed up to 24 weeks post-treatment. PRP injection led to significantly less leg pain at 6, 12 and 24 weeks follow-up compared to triamcinolone. No differences in back pain VAS scores or ODI scores were observed. The rate of treatment failure was not statistically different between groups; however, the 2 reported cases of treatment failure reported were both in the triamcinolone group. No adverse events were reported. The results suggest that PRP may be a viable alternative to steroids for lumbar disc herniation patients unresponsive to conservative treatment. Future studies with more patients and longer follow-up are required to confirm the results of this study.