OSTEOARTHRITIS
Autologous platelet-rich plasma versus hyaluronic acid, corticosteroids or saline for knee osteoarthritis: can blood draw volume serve as a proxy for platelet dose? A systematic review and meta-analysis.
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OrthoEvidence Journal (OE Journal) - ACE Report
Epub Ahead of Print
Int Orthop. 2026 01-May;():. 10.1007/s00264-026-06782-7Study Summary
62 randomized controlled trials including 4969 patients with symptomatic knee osteoarthritis were included in this systematic review and meta-analysis comparing intra-articular platelet-rich plasma (PRP) with hyaluronic acid (HA), corticosteroid, or saline. Pooled outcomes included Visual Analogue Scale (VAS) pain scores and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores at 6 and 12 months, as well as subgroup effects according to blood-draw volume. PRP significantly improved pain and function vs all comparators at 6 months and was superior to HA and corticosteroid at 12 months. Trials using at least 40 mL of blood generally demonstrated greater improvements than those using lower volumes. Overall, PRP may provide more durable symptomatic improvement than conventional injectable therapies.
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